Florian Greten

Prof. Greten’s research interests are signal transduction in cells of the tumour microenvironment and translational oncology using suitable mouse models. Prof. Greten studied at the Universities of Hamburg and Vienna. He graduated in 1998 at the University of Hamburg University before starting his internship at the Department of Medicine at the University Hospital in Ulm. From 2001-2004 he was a Postdoctoral Researcher at the University of California in San Diego, USA. Since October 2004 he works at the Klinikum rechts der Isar at the Department of Medicine and since beginning of 2001 at the Institute of Molecular Immunology. He was appointed Associate Professor of Molecular Gastrointestinal Oncology in 2010.

Awards

• Starting Grant, European Research Council (ERC) (2011)
• Dr. Emil-Salzer-Award (2010)
• AIO-Science Award (2010)
• Theodor-Frerichs-Award, German Society of Internal Medicine (2010)
• Johann-Georg-Zimmermann Award (2010)
• PRO SCIENTIA-Award, Eckhart-Buddecke-Foundation (2007)

Key Publications

• Bennecke et al: "Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor
  Progression during Alternative Colorectal Tumorigenesis".
  Cancer Cell. 2010; 18: 135-146.
• Bollrath et al: "gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell
  Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis".
  Cancer Cell. 2009; 15(2): 91-102.
• Greten FR et al: "NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed
  by Genetic and Pharmacological Inhibition of IKKβ". Cell, 2007;130(5): 918-31.
• Karin M, Greten FR: "NF-B: linking inflammation and immunity to cancer
  development and progression". Nat. Rev. Immunol. 2005; 5(10): 749-59.
• Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ,  Kagnoff MF, Karin M: "IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer". Cell. 2004; 118 (3): 285-296.